Basal levels of 17-hydroxyprogesterone can distinguish children with isolated precocious pubarche
نویسندگان
چکیده
منابع مشابه
Precocious pubarche in Thai children.
OBJECTIVE To describe the etiologies, clinical characteristics, and laboratory investigations of young Thai children being evaluated for precocious pubarche. MATERIAL AND METHOD The medical records of 41 children referred for evaluation of precocious presence of pubic hair at Songklanagarind Hospital between 1995 and 2011 were retrospectively reviewed. RESULTS The etiologies of precocious p...
متن کاملRelationship of CYP21A2 genotype and serum 17-hydroxyprogesterone and cortisol levels in a large cohort of Italian children with premature pubarche.
OBJECTIVE Premature pubarche (PP) is the most frequent sign of nonclassic congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency in childhood. The aim of this study was to assess the relationship between the CYP21A2 genotype and baseline and ACTH-stimulated 17-hydroxyprogesterone (17-OHP) and cortisol serum levels in patients presenting with PP. PATIENTS AND METHODS A total o...
متن کاملRaised 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
Congenital adrenal hyperplasia (CAH) refers to autosomal recessive diseases resulting from deficiency of enzymes involved in the production of cortisol by the adrenal glands. This study was designed to determine the frequency of suspected congenital adrenal hyperplasia patients by evaluating the laboratory data of blood 17-OHP. The study was conducted at Chemical Pathology Section of Department...
متن کاملPolycystic ovaries after precocious pubarche: relation to prenatal growth.
BACKGROUND In 1998, we revealed a sequence departing from prenatal growth restraint in girls and evolving, through precocious pubarche (PP) in mid-childhood, towards anovulatory and hyperinsulinaemic hyperandrogenism. The latter condition fulfilled the criteria for the diagnosis of polycystic ovary syndrome (PCOS), which was then defined independently of the presence of polycystic ovaries (PCOs...
متن کاملnon classic 21 hydroxylase deficient adrenal hyperplasia in patients with isolated precocious pubarche
precocious pubarche (pp) is most often a benign condition secondary to the early appearance of adrenarche. however, pp may be a manifestation of mild errors of steroidogenesis in particular non classic 21 hydroxylase deficiency (nc210hd). the incidence of nc210hd in patients with pp ranges from about 0-30% of cases in various reports. controversy exists as to whether all children with pp should...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2018
ISSN: 0031-3998,1530-0447
DOI: 10.1038/s41390-018-0096-7